Chronic Inflammation & Autoimmune Program — Stem Cell Therapy Istanbul

Specialized stem cell therapy program for chronic inflammation and autoimmune disorders at StemCell Longevita Istanbul. MSC therapy modulates the overactive immune system, reduces inflammation, and promotes tissue repair for conditions including rheumatoid arthritis, lupus, Crohn's disease, ulcerative colitis, COPD, pulmonary fibrosis, and Lyme disease.

Program Overview

Autoimmune diseases occur when the immune system mistakenly attacks healthy tissue. Our Chronic Inflammation & Autoimmune Program uses the immunomodulatory properties of Wharton's jelly-derived MSCs to recalibrate immune function, reduce chronic inflammation, and promote tissue repair — without the systemic suppression caused by conventional immunosuppressant drugs.

Led by Prof. Dr. Erdal Karaöz, this program integrates comprehensive immunological assessment, personalised MSC therapy, and a structured anti-inflammatory lifestyle protocol. With 14+ years of clinical experience and a UK corporate structure, we provide the accountability and transparency that international patients require.

Program at a Glance

• Expected Stay: 4–6 days in Istanbul
• Treatment Sessions: 2–3 MSC infusion sessions
• Follow-Up Program: Video consultations at 1, 3, 6, and 12 months
• Protocol: Wharton's jelly MSCs via IV infusion (200–300 million cells)
• Starting From: €8,950 all-inclusive

Your Treatment Journey

1. Immunological Assessment: Complete autoimmune panel (CRP, ESR, ANA), disease activity scoring (DAS28 for RA, SLEDAI for lupus), current medication review, and personalised treatment protocol design.
2. Clinical Evaluation in Istanbul: Physical examination and joint assessment at Liv Hospital Ulus, additional diagnostics, baseline disease activity documentation, and patient education on expected outcomes.
3. MSC Immunomodulation Therapy: GMP-certified Wharton's jelly MSC preparation, high-dose IV infusion (200–300M cells), 2–3 sessions, continuous monitoring, and anti-inflammatory adjunctive therapy.
4. Anti-Inflammatory Protocol: Personalised anti-inflammatory diet, gut microbiome optimisation, stress management, supplement protocol (vitamin D, omega-3, curcumin), and gradual medication tapering plan.
5. Long-Term Monitoring: Repeat inflammatory marker testing, disease activity re-scoring at 1, 3, 6, and 12 months, and second treatment cycle evaluation if needed.

Treatment Protocols

• High-Dose IV MSC Infusion: 200–300 million Wharton's jelly MSCs administered intravenously. MSCs modulate T-cell, B-cell, and dendritic cell function, shifting the immune response from pro-inflammatory (Th1/Th17) to anti-inflammatory (Th2/Treg) pathways.
• Sequential Dosing Protocol: Multiple infusions across treatment days allow for sustained immunomodulation and enhance the cumulative anti-inflammatory effect.
• Exosome Booster (Optional): MSC-derived exosomes provide additional cell-free immunomodulatory signalling, extending the therapeutic window.
• Gut-Immune Axis Support: Since 70% of the immune system resides in the gut, our protocol includes targeted nutrition and microbiome support to complement systemic immunomodulation.

Conditions Treated

Frequently Asked Questions

Can I continue my current medications during treatment?

Yes, most patients continue their medications during and after MSC therapy. Our medical team reviews your full medication list and advises on any adjustments. Some patients are able to gradually reduce immunosuppressant dosages over the following months under their home physician's supervision.

How do stem cells help autoimmune conditions?

MSCs are powerful immunomodulators. They recalibrate the overactive immune response by promoting regulatory T-cells (Tregs), reducing inflammatory cytokines, and suppressing autoreactive immune cells — without the broad immunosuppression caused by drugs like methotrexate or biologics.

Which autoimmune conditions respond best to MSC therapy?

Clinical evidence is strongest for rheumatoid arthritis, multiple sclerosis, lupus (SLE), and Crohn's disease. We also see promising outcomes in ulcerative colitis, Lyme disease complications, and other inflammatory conditions. Each case is individually assessed.

How long before results become noticeable?

Most autoimmune patients report initial improvements (reduced pain, better energy, decreased flare frequency) within 4–8 weeks. Maximum benefits typically develop over 3–6 months as the immune system recalibrates. Our 12-month follow-up tracks your progress throughout.