How does stem cell therapy treat multiple sclerosis?

MSCs reduce neuroinflammation, modulate the autoimmune attack on myelin, promote remyelination, and protect neurons from further damage. This can slow disease progression and improve neurological function.

Can stem cells repair myelin damage in MS?

MSCs release neurotrophic factors that support oligodendrocyte function and promote remyelination. While complete myelin repair depends on disease stage, many patients experience measurable neurological improvements.

What MS symptoms improve with stem cell therapy?

Patients report improvements in fatigue, mobility, balance, bladder function, cognitive clarity, and overall quality of life. MRI studies in some cases show reduced lesion activity after MSC treatment.

Is stem cell therapy available for progressive MS?

Yes. We treat both relapsing-remitting MS (RRMS) and progressive forms (PPMS, SPMS). While RRMS patients typically show the strongest response, progressive MS patients can also benefit from the neuroprotective effects of MSC therapy.

Stem Cell Therapy for ALS (Motor Neuron Disease): Research & Outcomes

The latest research on stem cell therapy for ALS and motor neuron disease. How MSC treatment may slow progression, protect motor neurons, and improve quality of life for ALS patients.

ALS and Neurodegeneration: How MSC Therapy Intervenes

ALS (amyotrophic lateral sclerosis) kills upper and lower motor neurons through a cascade involving protein aggregation (TDP-43, SOD1 misfolding), glutamate excitotoxicity, mitochondrial dysfunction, and neuroinflammation. MSC therapy targets the neuroinflammatory component: MSCs suppress microglial activation, reduce TNF-α and IL-1β production, and release neurotrophic factors (BDNF, GDNF, VEGF) that support surviving motor neurons. Intrathecal delivery achieves direct CSF contact with lumbar motor neuron pools.

What Evidence Exists for ALS MSC Therapy?

Phase I/II trials (Mazzini et al. 2003–2015, BrainStorm Cell Therapeutics NurOwn trials) established safety and showed slowing of ALSFRS-R decline in early-stage patients. Responder analyses indicate that fast-progressors (ALSFRS-R decline >1 point/month) and patients treated within 24 months of diagnosis show the most benefit. MSC therapy is not a cure for ALS but functions as a neuroprotective intervention that may extend the period of functional independence.

Who Should Consider MSC Therapy for ALS?

Best candidates: confirmed ALS diagnosis (excluding mimics), relatively preserved respiratory function (FVC >50%), within 36 months of symptom onset, and stable enough to travel. Our team conducts detailed pre-treatment eligibility assessment including neurological evaluation, pulmonary function testing, and review of genetic status (SOD1, C9orf72). Realistic expectations and shared decision-making are central to our consultation process.

Frequently Asked Questions

How does stem cell therapy treat multiple sclerosis?: MSCs reduce neuroinflammation, modulate the autoimmune attack on myelin, promote remyelination, and protect neurons from further damage. This can slow disease progression and improve neurological function.
Can stem cells repair myelin damage in MS?: MSCs release neurotrophic factors that support oligodendrocyte function and promote remyelination. While complete myelin repair depends on disease stage, many patients experience measurable neurological improvements.
What MS symptoms improve with stem cell therapy?: Patients report improvements in fatigue, mobility, balance, bladder function, cognitive clarity, and overall quality of life. MRI studies in some cases show reduced lesion activity after MSC treatment.
Is stem cell therapy available for progressive MS?: Yes. We treat both relapsing-remitting MS (RRMS) and progressive forms (PPMS, SPMS). While RRMS patients typically show the strongest response, progressive MS patients can also benefit from the neuroprotective effects of MSC therapy.

Stem Cell Therapy for ALS (Motor Neuron Disease): Research & Outcomes

ALS and Neurodegeneration: How MSC Therapy Intervenes

What Evidence Exists for ALS MSC Therapy?

Who Should Consider MSC Therapy for ALS?

Frequently Asked Questions

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