Regenerative Approach for Infertility
- Written by
- StemCell Longevita Editorial Team
- Medically reviewed by
- Prof. Dr. Erdal Karaöz TeamProfessor of Histology and Embryology · Medical Director, Center for Regenerative Medicine
- Last reviewed
- Next scheduled review
How we evaluate evidence · Conflict-of-interest disclosure · Editorial standards
Restore your fertility naturally with advanced regenerative medicine approach. Treatment for diminished ovarian reserve using your own cells with a 67%+ success rate.
Evidence at a glance — Female infertility and thin endometrium
A plain summary of what the published research does and does not show for this condition. It is written to the same standard whether the evidence is strong or weak.
- Human studies available?
- Yes — early-stage only
- Randomised trials?
- Small early-phase trials, mostly uncontrolled
- Main outcomes studied
- Endometrial thickness
- Ovarian reserve markers (AMH, AFC)
- Clinical pregnancy rate
- Safety
- Long-term evidence
- Very limited
- Regulatory approval for this indication
- United States (FDA): No FDA-approved mesenchymal stem cell product for this indication. The FDA has issued consumer warnings about unapproved stem cell products.
- European Union (EMA): No EMA-authorised mesenchymal stem cell medicine for this indication.
- United Kingdom (MHRA): No MHRA-authorised mesenchymal stem cell medicine for this indication.
- Türkiye (Ministry of Health): In Türkiye, cell therapies are delivered only inside Ministry of Health–licensed centres under the regenerative medicine / advanced therapy regulations, as clinical research or individual (exceptional) use — not as an approved routine treatment for this indication.
- Role at our centre
- Research context — considered only where standard care is exhausted or unsuitable, and never as a replacement for it
What kind of evidence exists
- Mechanism (laboratory): Documented
- Animal / preclinical: Documented
- Early human (phase 1/2, uncontrolled): Documented
- Controlled human (randomised or sham-controlled): Not established
- Regulatory approval: Not established
Sources
- Systematic reviews and meta-analyses — Female infertility and thin endometrium — PubMed
- Randomised controlled trials — Female infertility and thin endometrium — PubMed
- Registered MSC trials — Female infertility and thin endometrium — ClinicalTrials.gov
- FDA — Consumer alert on regenerative medicine therapies — U.S. Food and Drug Administration, 2024
- Advanced therapy medicinal products: overview — European Medicines Agency, 2025
- ISSCR Guidelines for Stem Cell Research and Clinical Translation — International Society for Stem Cell Research, 2021
- ISSCR Patient Handbook on Stem Cell Therapies — International Society for Stem Cell Research, 2020
Source links open filtered searches of PubMed and ClinicalTrials.gov plus regulator and professional-society pages, so you can read the current evidence yourself rather than a selected extract.
This summary is general information about the evidence base, not medical advice and not a promise of benefit. Whether any treatment is appropriate for you can only be decided after a medical review of your records.
What is Diminished Ovarian Reserve?
The amount of eggs in a woman's ovaries is referred to as her ovarian reserve. A woman with a large ovarian reserve has many eggs (follicles) in her ovaries. As a woman gets older, especially around age 35, her ovarian reserve begins to decline.
Among the signs of diminished ovarian reserve include inability to become pregnant, pregnancies ending in loss, and early menopause. However, regenerative medicine approach offers new hope by restoring ovarian function using your own cells.
When stem cells come into contact with the ovaries, they can reproduce healthy ovarian cells, potentially restoring fertility. the approach has shown a success rate of 67% or higher in improving egg quality and quantity.
Causes of Diminished Ovarian Reserve
Understanding the factors that can affect your fertility helps determine the best treatment approach.
Surgical Procedures
Previous ovarian tissue surgery, cyst removal, or any abdominal surgery affecting reproductive organs.
Medical Treatments
Chemotherapy for cancer, radiation therapy, or other medical treatments that may affect ovarian function.
Infections & Conditions
Abscess, pelvic infections, endometriosis, or polycystic ovarian syndrome affecting fertility.
Lifestyle Factors
Intensive smoking, excessive caffeine consumption, and other lifestyle factors that may diminish ovarian reserve.
Understanding the regenerative approach for fertility-related concerns
Fertility concerns require specialist reproductive assessment. A consultation reviews diagnosis, previous fertility treatment, current specialist care, and relevant records before considering whether a regenerative discussion is appropriate.
This page is for information and does not replace advice from your usual specialist. Eligibility, delivery route, and follow-up are determined only after an individual medical review.
Who may be considered?
Fertility suitability depends on the underlying cause, reproductive history, and current specialist care. Our team reviews records before recommending any regenerative approach:
- People with a documented fertility diagnosis who are seeking an additional regenerative option
- Patients with diminished ovarian reserve or premature ovarian insufficiency, assessed case-by-case
- People with endometrial or testicular factors after specialist evaluation
- Patients who want their existing fertility treatment and regenerative options reviewed together
How the clinical pathway is planned
The recommended plan is individualised after records are reviewed; it is not a fixed, one-size-fits-all treatment package.
- 1
Remote medical-record review
The team reviews diagnosis, history, imaging or test results, current medication, and the goals you want to discuss.
- 2
Clinical suitability assessment
A clinician considers whether a regenerative approach can be discussed safely, including the delivery route and the need for any further testing.
- 3
Written plan before travel
If appropriate, you receive a written outline of the proposed approach, expected visit schedule, exclusions, and coordination arrangements.
- 4
In-person confirmation and follow-up
The plan is reconfirmed after an in-person assessment in Istanbul, with remote follow-up arranged after the visit.
What the approach is intended to address
Any proposed regenerative rationale for fertility is subject to clinical uncertainty and should be discussed alongside—not instead of—care from a fertility specialist.
Evidence and outcomes vary by diagnosis, disease stage, delivery approach, and the individual. The consultation is the place to discuss what is known, what remains uncertain, and whether an approach is appropriate for you.
Expected timeline and follow-up
Reproductive changes cannot be guaranteed and are assessed alongside standard fertility care. Any follow-up plan is individualized:
- 1
Records review & planning
The team reviews fertility history, current investigations, and any specialist recommendations before discussing whether a regenerative protocol is appropriate.
- 2
Treatment visit
If approved, the protocol and delivery route are confirmed in person in Istanbul during the treatment visit.
- 3
Follow-up with your fertility team
Progress and next steps are reviewed remotely, alongside the care of your existing fertility specialist.
When treatment may not be appropriate
While MSC therapy is safe for most patients, certain conditions may be contraindications. Treatment is not suitable in the following situations:
- Active cancer or ongoing chemotherapy/radiation treatment
- Active systemic infections requiring IV antibiotics
- Severe organ failure (end-stage kidney, liver, or heart failure)
- Pregnancy or planned pregnancy within 3 months
- Known allergy to any component used in cell processing
- Undiagnosed abnormal bleeding or an unresolved reproductive-health diagnosis
Our medical team conducts a thorough screening process to identify any contraindications before treatment. If stem cell therapy is not appropriate for your situation, we will advise you honestly.
Questions to discuss before deciding
Travel and care-coordination path
Treatment at StemCell Longevita is an all-inclusive medical-travel program from your first consultation to your 12-month follow-up:
- 1
Free online consultation & medical record review
Your journey begins with a free remote consultation. Our medical team reviews your medical records, imaging, and history to assess suitability — no travel required at this stage.
- 2
Written personalized protocol & treatment plan
You receive a written, personalized treatment protocol and plan detailing the recommended cell dosing, delivery route, and expected schedule for your condition.
- 3
Travel booking with clinic assistance
Our team assists with your travel arrangements. Every package includes VIP airport transfer and a 5-star hotel stay with breakfast included for you and an accompanying family member.
- 4
On-arrival medical evaluation in Istanbul
On arrival you undergo an in-person medical evaluation at the JCI-accredited Liv Hospital Ulus in Istanbul before treatment begins.
- 5
Treatment days
Treatment is administered over your stay, with a typical total stay of 3-5 days including evaluation, treatment, and monitoring.
- 6
Return home & 12-month telemedicine follow-up
After returning home you receive a 12-month telemedicine follow-up program with regular remote check-ins to track your progress.
How Stem Cells Work for Infertility
Regenerative medicine approach for infertility addresses the underlying tissue damage and hormonal imbalances that impair reproductive function in both men and women. Mesenchymal stem cells (MSCs) promote gonadal tissue repair, restore hormonal balance, and create favorable conditions for natural conception.
In female patients, MSCs secrete ovarian growth factors that clinical studies suggest can rejuvenate ovarian tissue and reactivate dormant primordial follicles. This mechanism may improve ovarian reserve, egg quality, and responsiveness to fertility treatments in women with diminished ovarian function.
In male patients, stem cells promote the repair of seminiferous tubule architecture and support Sertoli cell function. Research indicates MSCs can improve spermatogenesis by restoring the testicular microenvironment necessary for healthy sperm production and maturation.
MSCs modulate reproductive hormonal pathways by supporting the hypothalamic-pituitary-gonadal axis. Clinical observations suggest this hormonal rebalancing helps normalize FSH, LH, estradiol, and testosterone levels critical for reproductive function in both sexes.
Stem cells repair endometrial tissue and improve uterine receptivity in women with thin endometrium or Asherman's syndrome. Their regenerative factors promote endometrial thickening, vascularization, and the expression of implantation markers necessary for successful embryo attachment.
Who Is a Good Candidate?
Regenerative medicine approach for infertility is suitable for patients with organic causes of reproductive dysfunction who want to improve their natural fertility or enhance assisted reproduction outcomes.
Ideal Candidates
- Women with diminished ovarian reserve (DOR) or premature ovarian insufficiency (POI) seeking to improve egg quality and follicular response
- Women with thin endometrium or Asherman's syndrome that limits embryo implantation success in IVF cycles
- Men with non-obstructive azoospermia or severe oligospermia caused by testicular tissue damage or dysfunction
- Couples with unexplained infertility who have not achieved pregnancy despite multiple assisted reproduction cycles
- Patients with age-related fertility decline who want to support reproductive tissue health alongside fertility treatments
May Not Be Suitable
- Patients with genetic causes of infertility (such as Turner syndrome or Klinefelter syndrome) that affect chromosomal reproductive development
- Women with active gynecological malignancies or men with active testicular cancer requiring oncological treatment
- Individuals with mechanical causes of infertility (blocked fallopian tubes, obstructive azoospermia) that require surgical correction
- Patients with severe untreated endocrine disorders (uncontrolled thyroid disease, hyperprolactinemia) that need primary hormonal management
What Results Can You Expect?
Reproductive tissue regeneration requires time aligned with natural hormonal cycles. The timeline varies based on the specific fertility challenge, patient age, and whether treatment is combined with assisted reproduction techniques.
Initial Recovery
The body adjusts to treatment with possible mild pelvic sensitivity. Stem cells begin integrating into reproductive tissue and initiating regenerative and hormonal signaling processes.
Early Improvements
Clinical studies suggest early hormonal improvements may be detected in blood work (AMH, FSH, estradiol levels). Men may see initial improvements in semen analysis parameters.
Progressive Results
Women may notice improved follicular response during monitoring. Endometrial thickness improvements become measurable. Men typically show progressive improvements in sperm count and motility.
Optimal Results
Reproductive function improvements are typically at their peak. This is often the recommended window to attempt natural conception or proceed with IVF/ICSI cycles for best outcomes.
Long-Term Benefits
Sustained reproductive tissue improvements with maintained hormonal balance. Ongoing fertility support may include follow-up treatments to maintain optimal reproductive tissue health.
Individual results vary. These timelines are based on clinical observations and are not guaranteed outcomes. Your specialist will provide personalized expectations during your consultation.
Patient Experiences
Real outcomes from patients who chose regenerative medicine at StemCell Longevita Istanbul
"My friends keep asking what I've done differently. I feel ten years younger — my energy, my skin, my mental clarity. It's been transformative."
"As a CEO, I can't afford to slow down. The rejuvenation programme in Istanbul was the best investment I've made in my health and my career."
How Our Infertility Treatment Works
A comprehensive regenerative medicine application program designed to restore ovarian function and improve fertility.
Comprehensive Evaluation
Complete endocrinological examinations and gynecological assessment to identify underlying causes.
Care Planning
Personalized protocol based on age, weight, and specific fertility challenges.
Stem Cell Extraction
Mesenchymal stem cells are harvested from your own adipose tissue in a hospital environment.
Laboratory Processing
Stem cells are carefully replicated in our certified laboratory for optimal potency.
Dual Administration
Cells delivered via intravenous access plus direct injection to the ovary region.
Follow-up Care
Regular monitoring to track improvements in ovarian reserve and egg quality.
Benefits of Regenerative Approach for Infertility
Discover how regenerative medicine can help restore your fertility naturally.
Restore Ovarian Function
Stem cells help regenerate healthy ovarian cells and restore reproductive function.
Improve Egg Quality
Treatment supports improvement in both the quality and quantity of eggs in the ovary.
Natural Approach
Uses your body's own stem cells with no risks of rejection or adverse effects.
67%+ Success Rate
High success rate in improving ovarian reserve when all other treatments have been exhausted.
Watch Our Patient Stories & Expert Insights
See real results and hear from our medical team about stem cell therapy treatments, procedures, and patient outcomes.
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Read ArticleHow Much Does This Cost Worldwide?
Compare this regenerative medicine costs at StemCell Longevita versus clinics in other countries.
| Country | Typical Cost |
|---|---|
| United States | $10,000 – $20,000 |
| United Kingdom | £8,000 – £15,000 |
| Germany | €10,000 – €18,000 |
| South Korea | $8,000 – $15,000 |
| StemCell Longevita (Turkey) | From £5,900 |
Prices based on market research of comparable stem cell clinics offering umbilical cord-derived MSC treatments (2025-2026). Actual prices vary by clinic, cell count, and condition.
Related clinical questions
Where this page sits in the wider picture.